Fouling of membranes in reverse osmosis systems can occur due to differential solubility of barium sulfate in solutions of different ionic strength.
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The partition coefficient ( Log P ) is a measure of differential solubility of a compound in a hydrophilic solvent ( water ).
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The nickname " Fraction V " refers to albumin being the fifth fraction of the original Edwin Cohn purification methodology that made use of differential solubility characteristics of plasma proteins.
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The difference is nevertheless small enough that the reaction can be driven to completion by exploiting the differential solubility of halide salts, or by using a large excess of the halide salt.
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Analogously, the " partition coefficient " a measurement of differential solubility and itself a component of QSAR predictions can be predicted either by atomic methods ( known as " XLogP " or " ALogP " ) or by chemical fragment methods ( known as " CLogP " and other variations ).
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